The Science of Alkaloids: Understanding Kratom’s Active Compounds

by seolinks786 on Aug 1st, 2025 22:22 PM

What Are Alkaloids?
Alkaloids are naturally occurring chemical compounds found in many plants. They often have strong effects on the human body, especially the brain and nervous system. In kratom, these alkaloids are responsible for its distinct properties. Two of the most notable are mitragynine and 7-hydroxymitragynine, known [color=#000000][size=2]stackd[/size][/color] for their unique actions.
Mitragynine: The Primary Alkaloid
Mitragynine is the most abundant alkaloid in kratom leaves. It interacts with various receptors in the body, including those linked to mood, discomfort, and energy. This alkaloid is known for producing stimulating effects at lower doses and more calming effects when used in higher amounts, depending on individual sensitivity.
7-Hydroxymitragynine: The Potent Derivative
7-Hydroxymitragynine, also called 7-OH, is found in much smaller quantities but is significantly more potent than mitragynine. It is often the main alkaloid used in extracts or enhanced kratom products. Even in tiny doses, 7-OH has strong effects, making accurate dosing and lab testing extremely important for safe usage.
How Alkaloids Interact with the Body
Alkaloids like mitragynine and 7-OH interact with receptors in the brain, particularly the mu-opioid receptors. These interactions influence sensations such as relaxation, alertness, and well-being. The unique profile of kratom’s alkaloids makes it different from other botanical supplements and gives it its well-known reputation among users.
The Role of Alkaloid Ratios
The effects of kratom depend not just on individual alkaloids but also on their ratios. A leaf with high mitragynine and low 7-OH will feel different from one with a more balanced profile. Extract products like those from 7OH Plus often focus on isolating or enhancing specific alkaloids for targeted results.
Lab Testing Ensures Alkaloid Accuracy
Because alkaloids are so powerful, it’s important to know exactly what’s in your product. 7OH Plus uses lab testing to confirm alkaloid content in every batch. This helps ensure safety, consistency, and transparency, which are crucial when working with concentrated substances like 7-hydroxymitragynine.
Why Some Products Feel Stronger
Customers often ask why some kratom products feel much stronger than others. The answer lies in alkaloid concentration. Extracts or isolates have higher levels of active compounds, especially 7-OH. These should be used with care. Lower-potency products have more balanced alkaloid profiles and are better for daily or beginner use.
Extraction and Isolation Methods
Advanced extraction techniques allow companies like 7OH Plus to isolate specific alkaloids. This creates purified products focused on potency and effectiveness. High-quality extraction removes unwanted plant matter while preserving the targeted compounds. The result is a cleaner, stronger, and more efficient supplement for experienced users seeking precision.
Understanding the Entourage Effect
Some users believe in the “entourage effect,” where multiple alkaloids work together to produce a more balanced experience. This is why some people prefer full-spectrum kratom over isolated extracts. 7OH Plus provides both options, allowing users to choose based on their personal needs, goals, and tolerances.
Conclusion: Science Supports Safe Use

Understanding kratom’s alkaloids helps you make informed decisions. Whether you're using mitragynine, 7-OH, or a full-spectrum blend, knowledge is power. 7OH Plus ensures each product is backed by science, lab-tested for safety, and crafted to deliver results you can trust with every dose you take.